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Vitamin K2+A+D3
Vitamin K2+A+D3

Vitamin K2+A+D3 Where-to-buy2015

NPN 80060826

      • Maintains eyesight, skin, immune function, bones, teeth and night vision

Bones
The combination of vitamins K and D has been shown to significantly increase bone mineral density (BMD) better than either alone. High-dose vitamin K has been shown to significantly reduce fractures in double-blind research of postmenopausal women with osteopenia. A review of seven controlled studies confirmed that high-dose vitamin K reduces the risk of fractures, and large amounts of vitamin K have been shown in preliminary research to correlate with greater BMD and to increase bone formation in some women. MK-7, the form of vitamin K in Vitamin K2+A+D3 has been shown to increase bone mineralization, to significantly reduce loss of BMD, improve bone strength and decrease risk of fracture in placebo-controlled research. K2 has also been shown to improve the ratio of bone formation to bone breakdown. A meta-analysis of thirteen controlled studies found that long-term high-dose vitamin K supplementation reduces bone loss.

Vitamin D has also been shown to increase bone density and to reduce hip fracture by 43-60%.

Eyesight & Night Vision
Vitamins D and A benefit the eyes. People with the highest vitamin D levels are 36% less likely to have macular degeneration. Vitamin A deficiency may cause, and supplementation may improve, night blindness. Doubleblind research shows that high-dose vitamin A can speed up recovery of light sensitivity and adaptation to dark.

Skin
Vitamins D and A are also good for your skin. Vitamin D can help adults with low levels of D and children treat eczema, and high-dose vitamin A has been shown to prevent acne.

Teeth
Vitamin K supports activation of proteins involved in tooth mineralization. People with the highest levels of D have 30% less risk of gingivitis. Vitamin D also helps periodontal disease because men with the highest levels of D have 39% less bone loss and women have 26% less: supplementation with vitamin D reduces bone loss.

Immunity
In people who are deficient in vitamin A, supplementing vitamin A can enhance immunity. Impressively, vitamin D reduces the risk of flu in kids by 42% during the winter.

Each Serving (0.25 mL) Contains:
Medicinal Ingredients:
Vitamin A (palmitate) . . . . .. . . . . . . . . . . . .. . . . . . . . . . . . . 151 mcg RAE (500 IU)
Vitamin D3 (cholecalciferol) . . . . . . . . . . . . . . . . . . . . . . . . . . .25 mcg (1000 IU)
Vitamin K2 (menaquinone-7) . . . .  . . . . . . . . . . . . . . . . . . . . . 50 mcg

Non-medicinal Ingredients: Medium chain triglycerides, olive oil, flaxseed oil, tocopherols, vanilla cream flavour.

Recommended dose (children (4 years & up) and adults): 1 serving (0.25 mL) daily or as directed by a health care practitioner.

References:

  1. Iwamoto J, Takeda T, Ichimura S. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis. J Orthop Sci 2000;5:546-51.
  2. Cheung AM, Tile L, Lee Y, et al. Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial. PLoS Med 2008 5:e196.
  3. Iwamoto J, Sato Y, Takeda T, et al. High-dose vitamin K supplementation reduces fracture incidence in postmenopausal women: a review of the literature. Nutr Res 2009;29:221-8.
  4. Feskanich D, Weber P, Willett WC, et al. Vitamin K intake and hip fractures in women: a prospective study. Am J Clin Nutr1999;69:74-9.
  5. Craciun AM, Wolf J, Knapen MH, et al. Improved bone metabolism in female elite athletes after vitamin K supplementation. Int J Sports Med 1998;19:479-84.
  6. Forli L, Bollerslev J, Simonsen S, et al. Dietary vitamin K2 supplement improves bone status after lung and heart transplantation. Transplantaion 2010;89:458-64.
  7. Knapen MH, Drummen NE, Smit E, et al. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int 2013;doi:10.1007/s00198-013-2325-6.
  8. Koitaya N, Sekiguchi M, Tousen Y, et al. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women. J Bone Miner Metab 2014;32:142-50.
  9. Cockayne S, Adamson J, Lanham-New S, et al. Vitamin K and prevention of fractures: systematic review and meta-analysis of randomized controlled trials. Arch Intern Med 2006;16:1256-61..
  10. Dawson-Hughes B, Dallal GE, Krall EA, et al. Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. Ann Intern Med 1991;115:505-12.
  11. Ooms ME, Roos JC, Bezemer PD, et al. Prevention of bone loss by viatamin D supplementation in elderly women: a randomized double-blind study. J Clin Endocrinol Metabol 1995;80:1052-58.
  12. Adams JS, Kantorovich V, Wu C, et al. Resolution of vitamin D insufficiency in osteopenic patients results in rapid recovery of bone-mineral density. J Clin Endocrinol Metab 1999; 84:2729-30.
  13. Dawson-Hughes B, Harris SS, Krall EA, et al. Rate of bone loss in postmenopausal women randomly assigned to one of two dosages of the vitamin D. Am J Clin Nutr 1995;61:1140-45.
  14. Chapuy MC, Arlot ME, Delmas PD, et al. Effect of calcium and cholecalfiferol treatment for three years on hip fractures in elderly women. Br Med J 1994;308:1081-82.
  15. Parekh N, Chappell RJ, Millen AE, et al. Association Between Vitamin D and Age-Related Macular Degeneration in the Third National Health and Nutrition Examination Survey, 1988 Through 1994. Arch Opthalmol 2007;125:661-69.
  16. Fok JS, Li JY, Yong TY. Visual deterioration caused by vitamin A deficiency in patients after bariatric surgery. Eat Weight Disord 2012 Jun;17:e144-6.
  17. Owsley C, McGwin G, Jackson GR, et al. Effect of short-term, high-dose retinol on dark adaptation in aging and early age-related maculopathy. Invest Ophthalmol Vis Sci 2006;47:1310-8.
  18. Samochocki Z, Bogaczewicz J,Jeziorkowska R, et al. Vitamin D effects in atopic dermatitis. J Am Acad Dermatol 2013 May 2 [Epub ahead of print].
  19. Camargo CA Jr, Ganmaa D, Sidbury R, et al. Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children. J Allergy Clin Immunol 2014;134:831-835.e1.
  20. Kugman A, Mills J, Leyden J. Oral vitamin A in acne vulgaris. Int J Dermatol 1981;20:278-85.
  21. Dietrich T, Nunn M, Dawson-Hughes B, et al. Association between serum concentrations of 25-OH vitamin D and gingival inflammation. AJCN 2005;82:575-80.
  22. Miley DD, Garcia MN, Hildebolt CF, et al. Cross-sectional study of vitamin D and calcium supplementation effects on chronic periodontitis. J Periodontol 2009;80:1433-9.
  23. Semba RD. Vitamin A, immunity, and infection. Clin Infect Dis 1994;19:489-99 [review].
  24. Urashima M, Segawa T, Okazaki M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr 2010;91:1255-60.

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