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EstroSense® Where-to-buy2015


NPN 80035630

What to expect from this product:

  • Promote Healthy Estrogen Metabolism

Reduce Estrogen Dominance

Symptoms of hormone imbalance are sparked by an imbalance of estrogen to progesterone, with estrogen being dominant – often referred to as Estrogen Dominance. Symptoms of Estrogen Dominance include: heavy or painful periods, hormonal acne, PMS, ovarian cysts, fibrocystic breasts, endometriosis and more… EstroSense is the ideal hormonal health partner for women using oral contraceptives and those suffering from the symptoms of hormonal imbalance.

EstroSense is a unique formula containing all natural ingredients to help maintain healthy hormone balance by promoting liver detoxification and healthy estrogen metabolism. It combines key ingredients such as calcium-d-glucarate, indole-3-carbinol, sulforaphane, and milk thistle for promoting liver detoxification and excretion of harmful estrogens. EstroSense also provides Tumeric, Lycopene, Rosemary and Green tea for powerful antioxidant support.

EstroSense is a complete natural formula that helps maintain lifelong healthy hormone balance from puberty onward.


Medicinal Ingredients
  • Calcium D-Glucarate… 75 mg
  • Indole-3-Carbinol (plant sourced)… 75 mg
  • Green Tea Extract (80% catechins)… 50 mg
  • Turmeric (95% Curcumin) … 25 mg
  • Milk Thistle Seed Extract (60% Silymarin)… 25 mg
    Rosemary Extract (6% Carnosic Acid)… 12.5 mg
  • Tomato Extract (lypopersicon esculentum) (fruit)...50 mg
  • Lycopene … 2.5 mg
  • Broccoli Powder (Brassica oleracea var. italica) (aerial)....27.5 mg
  • Sulforaphane… 100 mcg

Encapsulated in a vegetarian capsule, microcrystalline cellulose (cellulose, purified water, silica), L-Leucine, silica.

3 capsules daily taken with food or as directed by a health care practitioner.

I have a new bottle of EstroSense and I see that the ingredient DIM has been removed.  Can you tell me why?

DIM was removed from EstroSense because the NHPD (Natural Health Products Directorate) concluded at the time of licensing that there was not enough safety evidence for this ingredient in humans to support its inclusion in the formula.  Rest assured the removal of DIM will not change the benefits and effectiveness of EstroSense.  I-3-C remains in the product and this ingredient offers the same benefits as DIM, as they both have essentially the same action and effect in the body.  (I-3-C is a compound found in broccoli and other cruciferous vegetables that has been shown to promote healthy estrogen metabolism in humans, thereby helping to reduce the risk of estrogen-related cancers). 

Why does my new bottle of EstroSense smell so bad?

The strong smell of EstroSense comes from the glucosinolates, which are sulfur-containing compounds found in cruciferous vegetables - which in EstroSense are the indole-3-carbinol and the sulforaphane.  Remember that all the ingredients used in our products are only sourced from the highest quality suppliers available, always meet the quality standards established by Natural Health Product Directorate (NHPD) and the noticeable variations in the smell of EstroSense can be attributed to the inherent smell of the raw material ingredients used in the product’s formulation.

Why is there a caution on your EstroSense labels about low iron levels?

The iron deficiency caution on our new EstroSense label is derived from the Green Tea Extract Monograph (which can be found on the Health Canada website).  The new Health Canada regulations for NPNs require that we make reference to any and all cautions pertaining to the applicable monographs.

What is it about the Green Tea Extract that can affect iron absorption?

Green tea contains tannins that may affect iron absorption by forming a complex with the iron in the digestive tract and the resulted complex is not bio-available (only plant sources of iron are affected by tannins). 

What is "Sulforaphane"? Does it have anything to do with Sulpha drugs?

Our Sulforaphane is naturally occurring in broccoli and is obtained from broccoli. It has nothing to do with sulfa drugs.

Is the broccoli sprout extract in BroccoPhane non-GMO?

Yes, we have confirmation on file that this ingredient is non-GMO.

Is Lycopene (Lyc-O-Mato) from real tomato or synthetic?

Lycopene is naturally sourced from non-GMO tomatoes.

I am on the birth control pill. Can I still take EstroSense?

Absolutely, EstroSense should be taken while on the pill. This product protects women from the negative effects of the pill by helping to protect the liver from converting your estrogens into cancer causing estrogens. EstroSense does not lower or reduce the effectiveness of the pill for birth control.

Should I continue to take EstroSense while I have my period, or do I stop like I do with my birth control pill?

Yes, continue to take EstroSense during your period.

I have been on contraceptive pills for many years and am considering stopping.  Is it wise to take EstroSense if I do stop taking the pill?

EstroSense will help while on the pill by metabolizing the hormone by-products and converting them into friendlier compounds.  EstroSense will definitely be essential to take once an individual comes off the pill in order to help keep the liver strong and detoxify the many years of birth control hormones from the body.

I see that EstroSense contains milk thistle, but isn't milk thistle estrogenic?

We use milk thistle seed extracts in EstroSense and no, this is not an estrogenic ingredient - it is a very safe herb that can help your liver detoxify cancer causing estrogens.

How much elemental calcium (if any) is in the 150mg dosage of Calcium D-Glucarate that is in each EstroSense capsule?

Calcium D-Glucarate contains 16.15% calcium, therefore each capsule of EstroSense contains 12mg of elemental calcium (or 36mg per 3 capsule dose).

Who should take EstroSense?  Do I stop when I reach menopause?

Any female from the time she gets her first menstrual cycle and right through menopause, should be taking EstroSense.  Even if a woman has stopped menstruating, she will still be exposed on a daily basis to exogenous estrogens from the environment and may still have "bad" estrogens stored in the body's fatty tissue.  Also, many post-menopausal women do take HRT - which, like the birth control pill, has negative side effects that EstroSense can help counteract.

Your label doesn't specify what time of day I should take these capsules?

As long as you are taking the recommended dosage within a 12-hour day, then it really doesn't matter what time you take them. Many seem to prefer to take 1 capsule with each meal - breakfast, lunch and dinner. If someone would rather take all 3 capsules at once, that is fine too.

How long before I notice a difference by using EstroSense?

EstroSense was designed to help ensure that your hormones are balanced, to help halt ovarian pain and to help alleviate your PMS symptoms while normalizing your periods. You should notice EstroSense working within two to three menstrual cycles.

I have started taking EstroSense, but am now experiencing cramps and mid-cycle bleeding.  What could be happening?

EstroSense is important for supporting the liver and detoxification of unhealthy estrogens as well as helping to reduce inflammation.  If the liver is very congested then, in some cases, people may experience a cycle with increased cramping as the body is detoxifying.  If you are taking the full recommended dosage of EstroSense, you might want to consider minimizing your dosage in order to support a gentler detoxification.  If your cramping and mid-cycle bleeding persist, you should see your GP or ND and request an ultrasound, in order to determine what other possible underlying factors are at play.

I began taking EstroSense for painful cramps and in the hope to balance hormones as my partner and I are trying to conceive.  My last cycle I felt I had more cramps than usual and heavier bleeding plus spotting afterwards.  Why is this and what should I do?

Our recommendation would be to reduce the EstroSense dosage to 1 capsule daily and keep monitoring the spotting.  If it continues for longer than 10 days, stop taking the EstroSense and resume it again (1/day) for the next cycle.  For some women, EstroSense will make the first period after starting the product a little worse, and then the following cycles will show improvement.  EstroSense will remove any potentially harmful estrogens and support liver detoxification so the first cycle can be a bit worse because of this detox. process.

I have to take an over-the-counter anti-inflammatory just before and then during my period.  Can EstroSense help instead?

PMS and menstrual cramping usually involve inflammation caused by estrogen dominance.  Our EstroSense formula includes herbs to help support healthy metabolism of excess estrogens through the liver and to balance the body's estrogen/progesterone ratio.  Continue to take EstroSense during your period and over time you may not even have to take the anti-inflammatory anymore.

I am currently using Wild Yam cream. Can I use EstroSense also?

Yes, Wild Yam cream and EstroSense can be taken together.

Can I take EstroSense if I am taking Tamoxifin?

EstroSense should be fine to take with Tamoxifen.  Many of the ingredients in EstroSense can actually help minimize the side effects of the Tamoxifen.  The milk thistle seed extract and turmeric can help protect the liver from the ill effects of the drug, plus the antioxidants (lycopene, rosemary, green tea) can help protect recurrence of cancer and protect healthy cells.  Studies have also shown that indole-3-carbinol can actually help to assist Tamoxifin in reducing breast cancer recurrence without interfering with its effectiveness.

Is it safe to take EstroSense and Vitex together?

Yes, we recommend taking these two supplements together to possibly help with fertility issues, as well as with concerns regarding painful periods and heavy bleeding.  Vitex also supports natural progesterone production in the body and by combining this with EstroSense the body's estrogen and progesterone levels can be brought back into balance.

Can I take EstroSense and MenoSense together?

Yes you can, because ultimately EstroSense and MenoSense do different things:  EstroSense works directly with the liver to eliminate bad estrogens and help balance hormones; and MenoSense was developed to specifically help alleviate menopausal symptoms (such as hot flashes and night sweats).

Can men take EstroSense?

Yes, they can.  Just as women can experience estrogen dominance from xenoestrogens (exogenous estrogens from the environment), so can men. Calcium-d-glucarate, Indole-3-carbinol and sulphoraphane all help metabolize excess estrogen from the body through the liver.  Milk thistle and curcumin help support the liver for detoxification.  Lycopene, green tea and rosemary are all potent antioxidants - and all these ingredients are totally safe to be taken by men and are certainly not female specific.

Does EstroSense contain soy?

No, this product is soy free.

Is EstroSense gluten free?

Yes, we do have confirmation on file that there is no gluten added and no gluten present in EstroSense.  However, our manufacturing facility is NOT a gluten free facility, and as we do process products that contain gluten we are unable to confirm 100% that there is no possibility of cross contamination.

I recently bought a bonus bottle of EstroSense 150 capsules, and I was extremely disappointed in the packaging. The bottle is huge and when you open it, it's only 1/4 full. I don't understand why the bottle has to be so big - isn't this a waste of packaging in the day and age of being environmentally friendly? Why not at least put it in a smaller bottle? 150 capsules are 150 capsules, no matter what size the bottle is.

This has been an ongoing challenge with our bonus bottles. With Canadian label standards it has been difficult to get all the required print on our labels in both English and French while keeping the font large enough that it can be easily read. Also, this is a bonus bottle size which required us to use a larger bottle than the 120's so that there would be no confusion on the shelves at retail level. We have used smaller bottles in the past and have received feedback that the writing was too small and hard to read. We try our best to put our products in the smallest bottle possible in an effort to be mindful of the environment, and we do use recyclable plastic. 

Do all of your products have an NPN?

Yes, all of our products have been issued a Natural Product Number (NPN) by Health Canada – these numbers do appear on our labels.  Further Natural Health Product criteria and information can be found on the Health Canada website  Under the Food and Drugs Act items that are considered a food – for example, our protein powders and herbal teas – do not require an NPN. 

Are your capsules GMO free?

Yes, our vegetarian capsule shells, our gelatin capsule shells and our softgel shells are all non-GMO.

Are your products GMO free?

Preferred Nutrition is currently in the process of testing all of our products so that we can advise the public if any of them contain ingredients that come from genetically modified organisms or not.  Once the testing is complete we will indicate on our website, as well as on our product information sheets and on our labels.  This will be done as quickly as possible and on a product-by-product basis.

Why have your cautions and your recommended/suggested usages changed so dramatically on many of your labels?

The changes you are noticing to our suggested usage and cautionary statements have been at the directive of Health Canada.  There have been many regulatory changes with regards to Natural Health Products causing companies to change their labels accordingly.  We update our website, product information sheets and labels on the actual products to reflect these regulations as quickly as we possibly can.  Health Canada and the industry representing natural health products act according to the interest of consumers and their safety.  As a result, if there is any concern with an existing condition, a caution is added to advise the consumer to seek out feedback from their Health Care professional. 

Will this product help me lose weight?

There is no such thing as a "magic" pill or product - the only way to succeed (and maintain) true weight loss is by adopting a healthy lifestyle combining adequate exercise and proper nutrition. If you are concerned about poor eating habits or cravings, then we recommend you seek advice from a Nutritionist or Naturopath to obtain some guidance on healthy eating, as well as to investigate possible underlying (or undiagnosed) hormonal imbalances, which can make it harder to lose weight.  You might also want to consider speaking with a personal trainer to help you discover a fun fitness program that you enjoy - because, no matter what, in order to achieve and maintain any type of weight loss, exercise is required.  Our vitamins and supplements are designed to help you in your quest to a daily, healthy lifestyle, however it also requires effort on your part.

Where do you source your products from? 

Please be advised that all of our ingredients, including flavourings, are derived from natural ingredients and are ISURA tested & certified (in order to ensure the absence of GMOs, contaminants, heavy metals and adulteration).  All of our products are manufactured at a GMP facility certified by Health Canada.  All raw materials come in and are tested for purity, safety and potency.  If they do not meet our standards they are rejected and sent back or destroyed.  We use the highest quality ingredients available, and choose organic whenever we can.  Many of our products contain proprietary patented ingredients that have been clinically researched to help deliver optimal results and outstanding quality.

Are your products peanut free?

Following compliance with food regulations, in order to make a negative claim such as "peanut free", it would be necessary to insure a zero tolerance of any peanut traces, including the possibility of cross contamination.  Although our manufacturing facility has a policy in place for allergen control, there is no specific policy for peanuts, nor is there a specific "no peanut agreement" with our raw material suppliers.

Can your products be used after the expiry date has passed?

Supplements generally keep their potency long after the expiry date.  There is certainly no safety issues with consuming after the expiry date has passed however the potency degrades over longer periods of time.

If a product does not specify "vegetarian capsule", then what is it made from?

These capsules are gelatin capsules sourced from either pork or beef.

Are any of your products "vegan-friendly"?

Yes, AdrenaSense, EstroSense, MenoSense, BioSil, Medi-C Plus, Magnesium and MagSense (from our WomenSense and Preferred Nutrition product lines), the Healing Teas, our Ultimate Maca Energy products and the Ultimate VEGAN line are all vegan friendly.

Why can't I find any prices on your website?

Preferred Nutrition is the wholesale distribution company for the products on this website. However we sell exclusively to Health Food stores & selected Natural Pharmacies across Canada, not directly to the general public.  Because the prices of our products can vary from store-to-store, we are unable to list our suggested prices on our website.  We recommend you contact your local retailer and inquire about prices directly with them.

Can I purchase products directly from you?  I went to a health food store and the prices seem very expensive.

We distribute our products in Canada only and we sell directly to Health Food stores - since they have a personal commitment to the natural health lifestyle.  Consumers are then able to buy our products from knowledgeable staff that are genuinely interested in helping people be well - people who care!  Always be sure to look for in store promotions or coupons when you are making your purchases as this can help alleviate your cost concerns.

Do all health food stores carry all of your products?

To find Health Food stores in your area that carry our products, please click on "Store Locator" at the top of this screen.  All you have to do is enter your postal code and you will be given a list of retailers in the radius that you choose. We do recommend calling ahead to see if they stock the item you are looking for and in most cases if a store does not normally carry something, they will offer to do a special order for you.

Are any of your products tested on animals?

No, there is no animal testing on any of our products.

Should your supplements be taken with or without food?

Most of our products will specify directly on the bottle whether they should be taken with a meal or not.  If nothing is stated, then the choice is yours as to when the best time is for you to take them.  In general, however, most vitamin supplements should be taken with food because once eating starts the digestive process, enzymes and gastric juices are generated and usually the nutrients will be absorbed and assimilated better.

I like the sound of many of your products.  Am I able to take different formulas at the same time?

Yes, it's safe to combine various WomenSense products to help support the body in achieving optimal health.  The same applies to the Preferred Nutrition line, Dr. Whitaker's formulas and Brad King's.  If you are unsure of any combination, then please consult your Health Care Practitioner.

I have heard that drinking green tea along with my supplements will end up flushing out all the nutrients?  Is this true?

No, you are fine taking your supplements with green tea.  Coffee inhibits the absorption of nutrients, but the caffeine in green tea will not pose the same problem.

Can you tell me if I can combine any of your supplements with the medication(s) I am on, as prescribed by my doctor?

It is best to consult your Doctor or alternative Health Practitioner before taking any new supplements while on prescribed medication.  If you have been approved to add our supplement(s) to your daily regime, then we do recommend that you space the medication and the supplements out by at least one hour.

Can I take your products when I am pregnant or breastfeeding?

We are not able to make any recommendations with any of our products when it comes to pregnancy or while nursing.  You must contact your Health Practitioner, Naturopath or Pharmacist.

I understand that you put a recommended dosage on your labels, but I can take more or less than that, right?  And, really, do I have to take the product every day?

With regards to the recommended dosage, we would suggest you speak to your Doctor or Health Care Practitioner before increasing any amounts.  As with any supplement you can determine your amount based on your personal preference - if you find that a product works for you immediately then you should be fine to take it just on the days you feel you need it, but again we suggest you discuss this with you MD or HP.  Some consumers find that a product needs to be in their system for a few days to a few weeks before they notice results and/or feel the full benefits. 

I bought a bottle of your product, and although it seemed to feel lighter than usual, I didn't think much of it, until I opened the bottle and discovered that there is nowhere near the amount of capsules inside as there should have been.  How can this happen?

As part of our corporate policy and Good Manufacturing Practices (GMP) requirement, our procedures incorporate routine in-process checks plus a final examination of the finished product to ensure conformance to all aspects of quality, including correct product count.  There are a number of checks and balances performed by both Production and Quality Assurance personnel prior to, during, and after the packaging operations to ensure that product under-counts do not happen. Although product under-counts can happen, this occurrence is rare.  Should you discover that your bottle is far below the label claim count upon opening - we recommend you return it to your point of purchase as per our 100% customer satisfaction guarantee.

What is your 100% money-back (customer satisfaction) guarantee?

Our 100% money-back/customer satisfaction guarantee ensures that if a customer is not completely satisfied with their purchase, they can return the unused portion of the product (in its original packaging) back to their point of purchase and we will credit the Health Food store 100% of their purchase price from us.  We cannot dictate if a store will give cash back or an in-store credit, nor can we override store policies already in place ~ but we do promise to credit them, regardless of the reason for the return.

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Kim S, Kim SH, Hur SM, Lee SK, Kim WW, Kim JS, Kim JH, Chloe JH, Nam SJ, Lee JE, Yang JH (2009) Silibinin prevents TPA-induced MMP-9 expression by down-regulation of COX-2 in human breast cancer cells. Journal of Ethnopharmacol, 126(2):252-257

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Kim S, Chol JH, Lim HI, Lee SK, Kim WW, Kim JS, Kim JH, Choe JH, Yang JH, Nam SJ, Lee JE (2009) Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells. Phytomedicine, 16(6-7): 573 – 580

Wang HJ, Tashiro S, Onodera S, Ikejima T (2008) Inhibition of insulin-like growth factor 1 receptor signaling enhanced silibinin-induced activation of death receptor and mitochondrial apoptotic pathways in human breast cancer MCF-7 cells. Journal of Pharmacological Sciences, 107(3): 260-269

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(2009) Milk Thistle [Monograph]. Retrieved from Health Canada Natural Health Products Ingredients Database

(2008) Rosemary – Oral [Monograph]. Retrieved from Health Canada Natural Health Products Ingredients Database

(2008) Turmeric – Oral [Monograph]. Retrieved from Health Canada Natural Health Products Ingredients Database

(2006) Calcium D-Glucarate [Monograph]. Retrieved from Natural Medicines Comprehensive Database

(2006) Lycopene [Monograph]. Retrieved from Natural Medicines Comprehensive Database

(2006) Sulforphane [Monograph]. Retrieved from Natural Medicines Comprehensive Database


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